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BioCore SEC is a family of high performance, size exclusion chromatography columns designed for separating a broad range of biomolecules based on size. This column technology involves the creation of a neutral hydrophilic layer on the surface of specially designed, high-strength, monodispersed silica particles, in combination with well-established column packing processes.
BioCore SEC columns are suited for separating peptides, oligonucleotides, monoclonal antibodies, and related aggregates and fragments, thus having a broad application range in pharmaceutical, biopharmaceutical and academia research.
High column efficiency and high resolution
Minimal undesired interactions between the stationary phase and analytes, resulting in good peak shape and recovery
High mechanical strength for longer column lifetime
Broad application range, including small-molecule drugs, peptides, proteins, oligos, glycans, etc.
Product Name | SEC-120 | SEC-150 | SEC-300 | SEC-500 |
Functional Group | Diol | |||
Substrate | Monodispersed, high pore volume, porous silica particles | |||
Particle Size | 3 & 5 μm | |||
Pore Size | 120 Å | 150 Å | 300 Å | 500 Å |
Pressure Limit | >2500 psi (3 μm) >1500 psi (5 μm) | |||
Temperature Limit | 40 ℃ | |||
pH Range | 2-8 | |||
Calibration Curve(PEG) | 300-10000 | 500-15000 | 1000-50000 | 5000-200000 |
Calibration Curve(Glucan) | NA | 1000-30000 | 2000-100000 | 20000-500000 |
Calibration Curve(Globular protein) | NA | 5000-150000 | 10000-750000 | 20000-1500000 |
Application | Small-molecule drugs, peptides, glycans, small oligos | Small-molecule drugs, peptides, glycans, small oligos and small proteins | mAbs and aggregates | mAbs and high order aggregates, large proteins and large DNA/RNA |
Product Name | Particle Size (µm) | Length (mm) | ID (mm) | |
7.8 | 4.6 | |||
BioCore SEC-120 | 5 | 300 | B213-050012-07830S | B213-050012-04630S |
150 | B213-050012-07815S | B213-050012-04615S | ||
50 | / | B213-050012-04605S | ||
3 | 300 | B213-030012-07830S | B213-030012-04630S | |
150 | B213-030012-07815S | B213-030012-04615S | ||
50 | / | B213-030012-04605S | ||
BioCore SEC-150 | 5 | 300 | B213-050015-07830S | B213-050015-04630S |
150 | B213-050015-07815S | B213-050015-04615S | ||
50 | / | B213-050015-04605S | ||
3 | 300 | B213-030015-07830S | B213-030015-04630S | |
150 | B213-030015-07815S | B213-030015-04615S | ||
50 | / | B213-030015-04605S | ||
BioCore SEC-300 | 5 | 300 | B213-050030-07830S | B213-050030-04630S |
150 | B213-050030-07815S | B213-050030-04615S | ||
50 | / | B213-050030-04605S | ||
3 | 300 | B213-030030-07830S | B213-030030-04630S | |
150 | B213-030030-07815S | B213-030030-04615S | ||
50 | / | B213-030030-04605S | ||
BioCore SEC-500 | 5 | 300 | B213-050050-07830S | B213-050050-04630S |
150 | B213-050050-07815S | B213-050050-04615S | ||
50 | / | B213-050050-04605S | ||
BioCore SEC-1000 | 5 | 300 | B213-050100-07830S | B213-050100-04630S |
150 | B213-050100-07815S | B213-050100-04615S | ||
50 | / | B213-050100-04605S |