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BioCore SEC

BioCore SEC is a family of high performance, size exclusion chromatography columns designed for separating a broad range of biomolecules based on size.
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BioCore SEC is a family of high performance, size exclusion chromatography columns designed for separating a broad range of biomolecules based on size. This column technology involves the creation of a neutral hydrophilic layer on the surface of specially designed, high-strength, monodispersed silica particles, in combination with well-established column packing processes.

BioCore SEC columns are suited for separating peptides, oligonucleotides, monoclonal antibodies, and related aggregates and fragments, thus having a broad application range in pharmaceutical, biopharmaceutical and academia research.

Main Features

  • High column efficiency and high resolution

  • Minimal undesired interactions between the stationary phase and analytes, resulting in good peak shape and recovery

  • High mechanical strength for longer column lifetime

  • Broad application range, including small-molecule drugs, peptides, proteins, oligos, glycans, etc.

Specifications

Product Name

SEC-120

SEC-150

SEC-300

SEC-500

Functional Group

Diol

Substrate

Monodispersed, high pore volume, porous silica particles

Particle Size

3 & 5 μm

Pore Size

120 Å

150 Å

300 Å

500 Å

Pressure Limit

>2500 psi (3 μm)

>1500 psi (5 μm)

Temperature Limit

40 ℃

pH Range

2-8

Calibration Curve(PEG)

300-10000

500-15000

1000-50000

5000-200000

Calibration Curve(Glucan)

NA

1000-30000

2000-100000

20000-500000

Calibration Curve(Globular protein)

NA

5000-150000

10000-750000

20000-1500000

Application

Small-molecule

drugs, peptides,

glycans, small oligos

Small-molecule

drugs, peptides,

glycans, small

oligos and small

proteins

mAbs and aggregates

mAbs and high

order aggregates,

large proteins and

large DNA/RNA

Calibration Curve

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Applications

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Product Name

Particle Size

(µm)

Length

(mm)

ID (mm)

7.8

4.6

BioCore SEC-120

5

300

B213-050012-07830S

B213-050012-04630S

150

B213-050012-07815S

B213-050012-04615S

50

/

B213-050012-04605S

3

300

B213-030012-07830S

B213-030012-04630S

150

B213-030012-07815S

B213-030012-04615S

50

/

B213-030012-04605S

BioCore SEC-150

5

300

B213-050015-07830S

B213-050015-04630S

150

B213-050015-07815S

B213-050015-04615S

50

/

B213-050015-04605S

3

300

B213-030015-07830S

B213-030015-04630S

150

B213-030015-07815S

B213-030015-04615S

50

/

B213-030015-04605S

BioCore SEC-300

5

300

B213-050030-07830S

B213-050030-04630S

150

B213-050030-07815S

B213-050030-04615S

50

/

B213-050030-04605S

3

300

B213-030030-07830S

B213-030030-04630S

150

B213-030030-07815S

B213-030030-04615S

50

/

B213-030030-04605S

BioCore SEC-500

5

300

B213-050050-07830S

B213-050050-04630S

150

B213-050050-07815S

B213-050050-04615S

50

/

B213-050050-04605S

BioCore SEC-1000

5

300

B213-050100-07830S

B213-050100-04630S

150

B213-050100-07815S

B213-050100-04615S

50

/

B213-050100-04605S